I figure any movie that begins with a Pixies song can’t be all that bad. And “Stuck on You” isn’t. In fact, it’s quite good—another funny, sweet and politically uncorrect (but never demeaning) film from The Farrelly Brothers, still best known for hanging semen from Ben Stiller’s ear in “There’s Something about Mary.” The joke is that brothers Bob and Walt Tenor (Matt Damon and Greg Kinnear) are Siamese twins. They seem fairly well-adjusted to the unique situation that nature has put them in and are popular guys around Martha’s Vineyard, where they live and make a living flipping burgers. But Walt is a budding thespian, currently putting on a one-man show about Truman Capote. And when the acting bug bites hard—despite Bob’s penchant for on-stage panic attacks—the boys move to Hollywood so that Walt can chase his dream.

Unfortunately, the market for conjoined twins is limited in Tinseltown, and the boys are the laughingstock of every agency they set their four feet in. Through luck and sneaky circumstances, Walt lands the male lead in a new detective series opposite Cher (playing herself), and though the director has difficulty keeping Bob out of frame, the series becomes a hit. Success has a price, however, taking a toll on Bob’s relationship with his Asian Internet girlfriend while limiting Walt’s acting opportunities. Eventually, Bob and Walt wonder if separation is the answer to their problems or just another problem to add to the list.

If “Stuck on You” sounds like a love story—not between two brothers and the women who love them, but just between the two brothers—yeah, it kinda is. But it’s a very funny one; this is, after all, the Farrellys we’re talking about. Those two know how to mix outrageous humor with an endearing sweetness. Whereas most comedies just play mean, the Farrellys can generate big laughs that often originate in the heart. They have a genuine love for their characters, whether they be conjoined twins, retarded busboys, sleazy Hollywood managers or—most frightening of all—Cher. In a real change-of-pace role for him, Damon is good. But Kinnear is terrific, with a semi-smarmy presence and his expert comic timing. He’s really underrated as a comic actor. In the eye-candy role, Latino “It Girl” Eva Mendes shows a real flair for playing a hot, dumb babe with a bosom with mesmeric powers. Seymour Cassell does an amusing turn as Walt’s two-bit agent, who lives in a retirement home, rides around on a motorized scooter and sports the lamest toupee ever seen onscreen.

For the first half-hour, I thought it was merely okay, but the more it went on, the funnier it became and I ultimately liked it a lot. So how does “Stuck on You” rate in the Farrelly oeuvre? It may not be their best (that’s “Kingpin” and, to a lesser degree, “Mary"), but I’d put it up there alongside “Me, Myself & Irene.” It’s certainly better than “Dumb & Dumber” or “Shallow Hal.” The Brothers continue to prove they’re not much in the directorial department, but they know how to deliver laughs. I’ll happily get in line for them every time.

Rod Lott writes about pop culture, annoying celebrities and life’s other absurdities every day at Hitch Daily and he also publishes the long-running Hitch:The Journal of Pop Culture Absurdity which is actually made out of paper.